Science
Mechanism of Action
It primarily functions by inhibiting NF-κB activation to reduce pro-inflammatory cytokines, while also preventing collagen degradation through MMP-1 inhibition. Additionally, it provides antioxidant protection by scavenging reactive oxygen species.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Inhibits UVB-induced MMP-1 expression and enhances Type I procollagen synthesis at 0.1-0.5% concentration.
- 02 At 50 μM, it significantly reduced UVB-induced MMP-1 secretion by 84.4% and decreased inflammatory markers.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Practically insoluble in water, it shows high solubility in organic solvents. It is sensitive to high heat, so incorporation during an emulsion's cooling phase is recommended.
Conflicts
- Strong oxidizing agents
- Strong bases
Safety
Safety Profile
While not reviewed by CIR, it is present in commonly used botanical extracts. Oral toxicity studies suggest low acute toxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Amentoflavone is a valuable biflavonoid offering significant anti-inflammatory, anti-aging, and antioxidant benefits across all skin types with low irritancy.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources