Science
Mechanism of Action
This extract operates through multiple pathways to enhance skin health. Its robust antioxidant action involves direct free radical scavenging, inhibition of reactive oxygen species, and reduction of metal ion catalytic activity, potentially activating the Keap1/Nrf2/ARE signaling pathway. Anti-inflammatory effects are achieved by inhibiting key pro-inflammatory cascades, including nuclear factor kappa B/tumour necrosis factor-α (NF-κB/TNF-α), cyclooxygenase-2 (COX-2), p38 mitogen-activated protein kinases, and NOD-like receptor protein 3 (NLRP3). Furthermore, it targets hyperpigmentation by suppressing the mRNA expression of tyrosinase and tyrosinase-related proteins, alongside influencing microphthalmia-associated transcription factors. It also possesses antibacterial properties, possibly by altering bacterial cell surface hydrophobicity and membrane permeability.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 100% methanol leaf extract demonstrated significant anti-proliferative activity against AMoL THP-1 cell lines, achieving 100% cell death within 24 hours at concentrations as low as 0.1 mg/ml.
- 02 Diarylheptanoid compounds from A. officinarum restored cell viability and protected against oxidative stress in hydrogen peroxide-induced SH-SY5Y cells by reducing malondialdehyde, nitric oxide, and reactive oxygen species.
- 03 A chloroform extract of A. officinarum exhibited strong anti-Candida albicans activity.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Galangin, a key component, maintains stability in slightly acidic pH environments but degrades at basic pH. Formulation temperature is a critical consideration as heat treatment can significantly impact the content of secondary metabolites and the extract's antioxidant properties.
Safety
Safety Profile
No specific safety assessments from CIR or SCCS for Alpinia Officinarum Leaf Extract were found. While the oil of A. officinarum was reported to cause mild skin irritation in rabbits, a multi-herbal product containing A. officinarum was deemed safe in randomized human clinical trials.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Alpinia Officinarum Leaf Extract is a valuable botanical ingredient offering robust antioxidant, anti-inflammatory, and brightening benefits, compatible with all skin types, making it a promising active for diverse skincare applications.
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References
Sources