Science
Mechanism of Action
This extract exerts its beneficial effects through a rich phytochemical profile, including polyphenols, tannins, flavonoids, steroid glycosides, and alkaloids. Its anti-inflammatory action is primarily mediated by inhibiting the synthesis of histamine and prostaglandins, key mediators in inflammatory responses. Additionally, it demonstrates moderate antioxidant potential by actively scavenging free radicals. The extract also possesses broad-spectrum antimicrobial activity against various pathogens such as E. coli, Staphylococcus aureus, and Pseudomonas aeruginosa, alongside antifungal properties.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies demonstrated significant antioxidant activity at concentrations between 25-400 µg/ml, evidenced by hydrogen peroxide scavenging and reducing power.
- 02 Anti-inflammatory properties were observed in vitro within the 25-400 µg/ml range, through stabilization of rabbit red blood cell membranes and prevention of protein denaturation.
- 03 Further in vitro investigations at 400 µg/ml, 800 µg/ml, and 1000 µg/ml confirmed significant inhibition of protein denaturation, highlighting its anti-rheumatoid and anti-inflammatory potential.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Animal toxicity studies involving oral administration of 1500 mg/kg/day of hot ethanol and hot water extracts to Wistar Albino rats for 42 consecutive days showed no acute or chronic toxic effects on hepatic or nephritic function, blood counts, external morphology, or organ weights.
Your Skin
Skin Compatibility
Our Assessment
Verdict
ALPINIA CALCARATA RHIZOME EXTRACT is a valuable botanical ingredient, demonstrating promising in vitro antioxidant, anti-inflammatory, and antimicrobial properties that make it suitable for formulations targeting various skin concerns, pending further in vivo human efficacy and safety assessments.
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References
Sources