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Moumoujus

ALPHA-PINANOL.

Avoid CAS 4948-28-1 / PERFUMING

ALPHA-PINANOL is a monoterpene derivative with potential biological activities, although its direct efficacy on skin remains largely unstudied. While its structural analog, alpha-pinene, exhibits notable antioxidant, anti-inflammatory, and photo-protective properties, ALPHA-PINANOL itself is classified with significant hazard statements, including skin and eye irritation.

Summary

Antioxidant Anti-inflammatory Photo-protective Antimicrobial Wound Healing Fragrance/Perfuming

Science

Mechanism of Action

While specific mechanisms for ALPHA-PINANOL on skin are not extensively documented, insights are drawn from its structurally related compound, alpha-pinene. Alpha-pinene is known to prevent UVA-induced oxidative stress by inhibiting reactive oxygen species (ROS) generation and reducing lipid peroxidation in human keratinocyte cells. It aids in mitigating UVA-induced photo-aging by preserving intracellular antioxidants, modulating Bax/Bcl-2 expression, and hindering the activation of apoptotic mediators like caspase-3. Furthermore, alpha-pinene demonstrates the capacity to suppress metalloproteinases and inhibit UVA-induced activation of proangiogenic and inflammatory protein expression, contributing to photo-aging prevention. It also exhibits anti-inflammatory, antimicrobial, and wound healing properties, including accelerated wound closure and enhanced collagen deposition.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Store in a cool place. Avoid prolonged or repeated exposure.

Conflicts

  • Strong oxidizing agents
  • Reducing agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

ALPHA-PINANOL (cis-2-Pinanol or 2-Pinanol) is classified with hazard statements indicating it is harmful if swallowed, harmful/toxic in contact with skin, and causes skin and serious eye irritation. Precautionary measures advise avoiding skin and eye contact and utilizing appropriate protective gear. The FDA's authorization of the related compound, alpha-pinene, for specific food contact uses does not extend to the cosmetic safety status of ALPHA-PINANOL itself, which lacks CIR review.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite potential skincare benefits extrapolated from related compounds, ALPHA-PINANOL is classified with significant hazard warnings for skin and eye irritation and toxicity, rendering its use in precision skincare highly inadvisable without comprehensive direct safety and efficacy data.

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