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Moumoujus

ALOE SPECIES RESIN.

Valuable CAS 84837-08-1 / PERFUMING

Aloe Species Resin, derived from the latex of various aloe plants, is rich in bioactive compounds like aloesin. This ingredient is scientifically recognized for its multifaceted benefits, including significant hyperpigmentation reduction and potent anti-inflammatory effects, making it a valuable addition to precision skincare formulations.

Summary

Skin Brightening Anti-inflammatory Antioxidant Anti-aging Soothing Moisturizing Wound Healing

Science

Mechanism of Action

Aloe Species Resin, primarily through its active constituent aloesin, functions as a competitive inhibitor of tyrosinase, the enzyme central to melanin synthesis, thereby effectively reducing unwanted skin pigmentation and lightening dark spots. Beyond its depigmenting action, it exhibits notable antioxidative properties, safeguarding the skin from free radical damage and contributing to delayed photoaging. Furthermore, aloesin provides anti-inflammatory benefits, which can soothe irritated skin and diminish redness, while also supporting the skin's natural moisture barrier and promoting cellular immune function restoration following UV exposure.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Aloesin, a key component of aloe resin, demonstrated a 34% reduction in UV-induced pigmentation in human skin when applied four times daily over 15 days. This effect was observed to be dose-dependent, indicating a direct correlation between concentration and melanin inhibition.
  2. 02 In vitro studies confirm that aloesin modulates melanogenesis by competitively inhibiting tyrosinase activity, thus directly decreasing melanin production.
  3. 03 Aloe resin I, an isolate from Cape Aloe, exhibited anti-inflammatory efficacy comparable to aloesin in reducing oedematous response in mice.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH 4.8 – 6
0 7 14

Stability

Cream formulations incorporating aloe resin demonstrate stability within a pH range of 4.8 to 6, closely mirroring the skin's physiological pH. The ingredient itself is characterized as a hard, solid substance in its dried form.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has not issued a definitive 'safe as used' or 'safe with restrictions' statement specifically for ALOE SPECIES RESIN due to insufficient data. While its key active, aloesin, is generally considered gentle with a low potential for topical irritation, it's important to differentiate from ingested forms: the U.S. FDA mandated removal of oral OTC laxatives containing aloe latex (resin) in 2002 due to safety concerns regarding anthraquinone glycosides upon ingestion.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Aloe Species Resin, particularly its active component aloesin, is a valuable ingredient for targeting hyperpigmentation, soothing inflammation, and offering antioxidant protection across all skin types.

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