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Moumoujus

ALLOFERON-1.

Valuable / BLEACHING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

Alloferon-1 is an immunomodulatory peptide targeting inflammation and enhancing innate immune responses. It offers significant soothing and anti-inflammatory benefits, making it suitable for calming sensitive or compromised skin.

Summary

soothing antioxidant anti-inflammatory immunomodulatory

Science

Mechanism of Action

This peptide stimulates Natural Killer cell cytotoxicity and induces interferons. It also modulates pro-inflammatory cytokines (IL-6, IL-8, TNF-α) and reduces vascular permeability, enhancing innate immunity via the NF-κB pathway.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7.5
0 7 14

Stability

Highly water-soluble, particularly as a TFA salt, but prone to enzymatic degradation and potential self-assembly in saline solutions. Storage at -20°C is recommended for raw material longevity.

Conflicts

  • Proteolytic enzymes
  • Strong oxidizing agents
  • Extreme pH conditions (<4.0 or >8.0)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While not reviewed by CIR or SCCS for cosmetic use, it is registered as an antiviral drug. Drug trials indicate it is non-toxic, non-mutagenic, and non-teratogenic.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Alloferon-1 is a valuable immunomodulatory peptide that provides potent anti-inflammatory and soothing effects, bolstering the skin's natural defenses and improving resilience.

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