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ALLANTOIN GALACTURONIC ACID.

Valuable CAS 5119-24-4 / SKIN CONDITIONING, SKIN PROTECTING, SOOTHING

Allantoin Galacturonic Acid is an advanced complex derived from allantoin, engineered to soothe and protect the skin. It supports the natural healing process by promoting cell renewal and mitigating inflammatory responses, leading to smoother and more hydrated skin.

Summary

Skin protecting Soothing Keratolytic Cell regeneration Anti-inflammatory Hydrating

Science

Mechanism of Action

This ingredient operates by leveraging the well-documented actions of allantoin. It functions as a keratolytic agent, gently facilitating the shedding of the stratum corneum to refine skin texture and remove dead cells. Crucially, it stimulates the proliferation of keratinocytes and fibroblasts, vital for robust wound healing and epidermal regeneration. Furthermore, Allantoin Galacturonic Acid modulates inflammatory pathways, notably by downregulating pro-inflammatory cytokines such as TNF-α and IL-6, thereby diminishing oxidative stress and inflammation. It also contributes to enhanced skin hydration by elevating the water content within the extracellular matrix.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 9
0 7 14

Stability

Based on allantoin, this complex demonstrates stability within a broad pH range, generally between 3.0 and 9.0, and can withstand prolonged heating up to 80°C. It is typically compatible with cationic, anionic, and non-ionic systems, and integrates well with other cosmetic components.

Conflicts

  • Strong acids
  • Strong bases
  • Acidic environments (pH < 3.5)

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Allantoin Galacturonic Acid is safe for use in cosmetic products. However, the panel identified data gaps concerning the specific use and concentration levels of allantoin complexes, including this ingredient. Galacturonic acid, a common food component, was not deemed a safety concern. Allantoin itself is approved by the FDA as an active ingredient in OTC skin protectant drugs at concentrations ranging from 0.5% to 2%.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Allantoin Galacturonic Acid is a valuable, CIR-approved complex, expected to deliver the well-regarded soothing, healing, and hydrating benefits of allantoin across all skin types, despite specific clinical efficacy data for the complex itself being limited.

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