Science
Mechanism of Action
Allantoin Calcium Pantothenate functions as a molecular complex delivering potent skin protectant, anti-irritant, soothing, and humectant properties. It actively stimulates regenerative processes, including wound healing and epithelization on damaged skin. Its allantoin component establishes a protective barrier to lock in moisture and shield against environmental irritants, concurrently fostering the development of new skin cells. Additionally, allantoin contributes moisturizing, anti-inflammatory, antioxidant, and keratolytic effects, aiding in the softening of skin proteins and the gentle removal of dead skin cells.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Easily integrated into formulations, demonstrating anti-irritant, healing, and conditioning capabilities across a broad spectrum of cosmetic and OTC applications. It effectively addresses skin irritation and lesions, particularly in after-sun, shave, and baby care products. Users experience a notable moisturizing effect and relief from itching, burning, chafing, and cracking associated with dry and sensitive skin. It also supports soothing and healing in antiperspirant, after-shave, and post-depilatory formulations.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient is soluble in water and glycerin, shows slight solubility in propylene glycol, and is insoluble in oils. Its allantoin component generally requires water to be heated to at least 65°C for complete dissolution, as its solubility at room temperature is limited to approximately 0.5%. The complex maintains stability within a pH range of 4.0 to 8.0. To prevent degradation, it must be protected from high temperatures and highly acidic environments (pH below 3.5).
Conflicts
- strong acids
- strong bases
- acidic environments (pH < 3.5)
Safety
Safety Profile
Allantoin Calcium Pantothenate is considered safe for use as an anti-irritant, healing, and conditioning agent in cosmetic and OTC products, with a maximum concentration of 2%. Its allantoin component is recognized by the FDA as an OTC skin protectant (0.5% to 2.0%) and is globally approved for cosmetic use by regions including the EU, Japan, and ASEAN. The CIR Expert Panel has confirmed allantoin's safety up to 2%. Calcium Pantothenate and its derivatives have been deemed safe in cosmetics by the CIR Panel and are GRAS by the FDA as a direct food additive. Isolated cases of allergic contact dermatitis to calcium pantothenate exist, but are considered rare individual sensitivities.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Allantoin Calcium Pantothenate is a valuable ingredient, expertly combining soothing, protective, and regenerative properties to improve skin health across all skin types and diverse product applications.
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