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ALLANTOIN BIOTIN.

Valuable CAS 4492-73-3 / ANTI-SEBUM, SKIN CONDITIONING, SKIN PROTECTING, SOOTHING

Allantoin Biotin is a precision skin-conditioning agent that combines the soothing, regenerating properties of allantoin with biotin's skin-smoothing benefits, promoting a healthier, balanced complexion.

Summary

Skin Conditioning Antiseborrhoeic Skin Protecting Soothing Keratolytic Moisturizing Anti-Irritant Cell Regeneration Wound Healing Collagen Synthesis Skin Smoothing

Science

Mechanism of Action

This complex functions as a multifaceted skin-conditioning agent. Its allantoin component offers keratolytic properties, gently softening and aiding in the exfoliation of dead skin cells for a refined skin texture. Allantoin also provides significant moisturizing, anti-irritant, and soothing benefits, actively promoting cell regeneration and stimulating fibroblast activity essential for collagen synthesis and wound healing. Biotin, the other constituent, further enhances skin conditioning and contributes to a smoother feel. Collectively, Allantoin Biotin is also noted for its antiseborrhoeic action, assisting in the regulation of sebum production.

Research

Clinical Evidence

High confidence
Effective range 0.5–2%
Optimal

2%

Key findings

  1. 01 Allantoin, a primary component, is officially recognized by the FDA as a skin protectant at concentrations between 0.5% and 2.0% in over-the-counter drug products.
  2. 02 Therapeutic studies utilizing formulations containing allantoin, at concentrations up to 4.0%, reported no adverse effects, suggesting a favorable safety profile at higher functional levels for its component.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 8
0 7 14

Stability

Allantoin Biotin, primarily attributed to its allantoin component, demonstrates stability within a pH range of 3 to 8 and tolerates prolonged heating up to 80°C. For optimal formulation, a pH between 4 and 8 is recommended. Water solubility can present challenges at concentrations exceeding 0.5%; proper dissolution requires addition to water at 50°C, or at 25°C with consistent stirring, to prevent recrystallization. It exhibits insolubility in commonly used oils.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
2%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded Allantoin Biotin, alongside other allantoin complexes and allantoin itself, is safe for cosmetic use. Allantoin has been rigorously tested and found to be non-irritating to eyes and skin, non-phototoxic, and non-mutagenic in bacterial tests. While biotin alone has a reported maximum leave-on concentration of 0.1%, the complex itself is deemed safe for use up to 2.0%. The FDA acknowledges allantoin as an effective skin protectant within a 0.5% to 2.0% concentration range for over-the-counter drug products.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Allantoin Biotin is a valuable ingredient, offering broad benefits from soothing and cellular regeneration to sebum regulation and skin protection, making it highly compatible across all skin types and a diverse range of cosmetic formulations.

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