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ALLANTOIN ACETYL METHIONINE.

Valuable CAS 4207-40-3 / ANTISTATIC, SKIN CONDITIONING, SKIN PROTECTING, SOOTHING

ALLANTOIN ACETYL METHIONINE is a highly effective derivative known for its significant soothing and reparative properties. It adeptly calms irritated skin, supports robust skin barrier function, and aids in the healing of acne lesions. This ingredient promotes overall skin health and resilience across various skin types.

Summary

Anti-irritant Healing Anti-acne Anti-seborrhoeic Skin conditioning Skin protecting Soothing Mild exfoliating Moisture retention Barrier reinforcing Cell renewal

Science

Mechanism of Action

ALLANTOIN ACETYL METHIONINE functions primarily as an anti-seborrhoeic and healing agent, mitigating irritation and fostering the recovery of acne-prone skin. Its allantoin component stimulates the proliferation of new skin cells and rejuvenation, directly contributing to enhanced wound healing and tissue repair. The ingredient also provides a mild exfoliating action for a smoother skin surface, assists in moisture retention, and reinforces the skin barrier through the renewal of keratinocytes, resulting in a softer and more supple complexion.

Research

Clinical Evidence

High confidence
Effective range 0.2–2%
Optimal

0.5%

Key findings

  1. 01 Concentrations between 0.2% and 0.5% demonstrate significant anti-irritant and healing effects, particularly beneficial for scalp conditioners by imparting elasticity and softness to hair.
  2. 02 At concentrations ranging from 1% to 2%, it is effectively integrated into anti-acne formulations, contributing to the healing of acne lesions and soothing irritated skin.

Transparency

Dusting Analysis

Not commonly dusted

Given its established efficacy at lower concentrations (0.2-0.5% for anti-irritant benefits) and its regulatory-approved maximum cosmetic use concentration of 2%, ALLANTOIN ACETYL METHIONINE is efficiently utilized without necessitating excessively high percentages that would suggest 'dusting'.

The Formula

Formulation

Solubility
Both
Optimal pH 3 – 8
0 7 14

Stability

The allantoin component exhibits stability within a pH range of 3 to 8 and can withstand prolonged heating at 80°C. For optimal integration into formulations, a pH between 4 and 8 is recommended. Water solubility at concentrations exceeding 0.5% can be optimized by dissolving it in water at 50°C or by adding it at 25°C under continuous stirring for proper dispersion.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
2%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has determined allantoin and its derivatives, including ALLANTOIN ACETYL METHIONINE, to be safe for cosmetic applications at concentrations up to 2%. The FDA OTC Topical Analgesic Review Panel classifies allantoin as a Category I (safe and effective) skin protectant within the 0.5% to 2% range. It receives 'LOW' concern ratings from EWG's Skin Deep for cancer, allergies, immunotoxicity, and developmental toxicity, and is rated 'Teen SAFE', 'Baby SAFE', 'Eyelid SAFE', and 'Irritant Free' by SkinSAFE.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

ALLANTOIN ACETYL METHIONINE is a valuable multi-functional ingredient, offering robust soothing, healing, and skin barrier-supporting benefits across all skin types with an excellent safety profile and well-defined efficacy at precise concentrations.

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