Science
Mechanism of Action
This extract primarily functions through specific peptides (molecular weight < 2000 Da) that bolster the skin's mechanical barrier by restoring tight junctions and stimulating ZO-1 synthesis. Simultaneously, these peptides strengthen the biological barrier by upregulating Toll-Like Receptor (TLR-2) expression in keratinocytes. Furthermore, traditional use highlights its anti-inflammatory, antioxidant, and detoxifying properties, with compounds like Alisol F demonstrating significant anti-inflammatory activity via inhibition of MAPK, STAT3, and NF-κB pathways.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Peptides obtained from Alisma plantago-aquatica rhizomes, comprising at least 90% by weight of total proteins and 8% by weight of dry matter in the active principle, strengthen the skin's mechanical barrier by restoring tight junctions and stimulating ZO-1 synthesis. These peptides also reinforce the biological barrier by stimulating TLR-2 receptor expression in keratinocytes.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
No specific safety assessments by the Cosmetic Ingredient Review (CIR) or SCCS for the cosmetic use of Alisma Plantago Aquatica Extract were identified. While Alisma orientale, a closely related species, has been associated with potential hepatotoxicity when consumed orally in traditional medicine, this concern pertains to internal consumption of a different variety and not topical application of Alisma Plantago Aquatica Extract.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Alisma Plantago Aquatica Extract is a valuable ingredient for fortifying skin barrier integrity and offering supplementary anti-inflammatory benefits, though further comprehensive clinical data would enhance its profile.
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References
Sources