Science
Mechanism of Action
This extract operates through several key mechanisms to promote skin health. It acts as an antioxidant by scavenging free radicals, thereby mitigating oxidative stress from environmental aggressors like pollution and UV radiation, which helps to minimize the appearance of fine lines. Its anti-inflammatory and anti-allergenic effects are attributed to active constituents, alisol B and alisol B 23-acetate, which inhibit 5-lipoxygenase (5-LOX)-catalyzed leukotriene (LT) production and β-hexosaminidase release in allergic responses. Additionally, it can reduce nitrite accumulation in LPS-activated macrophages, further underscoring its anti-inflammatory capacity. Beyond soothing, Alisma Orientale Extract helps regulate sebum production, reducing unwanted shine, and contributes to a brighter complexion. In cellular models, a 70% ethanol extract has also shown to inhibit lipid droplet formation and adipocyte differentiation by downregulating peroxisome proliferation-activity receptor γ (PPARγ).
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Inhibition of 5-lipoxygenase (5-LOX)-catalyzed leukotriene (LT) production and β-hexosaminidase release in rat basophilic leukemia cells at 1-10 µM concentrations, indicating anti-allergic potential.
- 02 Dose-dependent inhibition of lipid droplet formation and adipocyte differentiation in OP9 cells, primarily during early adipogenesis, via downregulation of PPARγ and related genes, using a 70% ethanol extract.
Transparency
Dusting Analysis
Information regarding dusting practices for Alisma Orientale Extract is not available in the provided research data.
The Formula
Formulation
Stability
Optimal pH range for stability is not explicitly available in the provided search results.
Safety
Safety Profile
Alismatis rhizoma extracts are considered generally safe and well tolerated based on extensive traditional use and animal toxicity studies for oral administration. A 90-day repeated oral dose toxicity study of an aqueous extract in rats showed no signs of toxicity or mortality up to 2,000 mg/kg/day, establishing a no-observed-adverse-effect level (NOAEL) greater than 2,000 mg/kg/day. Acute oral toxicity (LD50 > 4,000 mg/kg) and repeated dose oral toxicity (LD50 > 2,000 mg/kg) studies in SD rats also support its safety for oral routes. Maximum concentration for topical cosmetic use is not yet established by regulatory bodies.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Alisma Orientale Extract is a valuable botanical ingredient, offering comprehensive benefits including antioxidant protection, significant anti-inflammatory and anti-allergenic effects, and skin oil balance, with a low risk of irritation and broad skin type compatibility.
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