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ALISMA ORIENTALE EXTRACT.

Valuable CAS 168456-51-7 / SKIN PROTECTING

Alisma Orientale Extract is a botanical active renowned for its multi-faceted benefits, including robust antioxidant and anti-inflammatory properties. It effectively targets skin sensitivity and irritation, while also contributing to balanced oil production and overall skin brightening. This ingredient supports comprehensive skin health and resilience.

Antioxidant Anti-inflammatory Anti-allergenic Oil-balancing Skin brightening Soothing

Science

This extract operates through several key mechanisms to promote skin health. It acts as an antioxidant by scavenging free radicals, thereby mitigating oxidative stress from environmental aggressors like pollution and UV radiation, which helps to minimize the appearance of fine lines. Its anti-inflammatory and anti-allergenic effects are attributed to active constituents, alisol B and alisol B 23-acetate, which inhibit 5-lipoxygenase (5-LOX)-catalyzed leukotriene (LT) production and β-hexosaminidase release in allergic responses. Additionally, it can reduce nitrite accumulation in LPS-activated macrophages, further underscoring its anti-inflammatory capacity. Beyond soothing, Alisma Orientale Extract helps regulate sebum production, reducing unwanted shine, and contributes to a brighter complexion. In cellular models, a 70% ethanol extract has also shown to inhibit lipid droplet formation and adipocyte differentiation by downregulating peroxisome proliferation-activity receptor γ (PPARγ).


Research

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Inhibition of 5-lipoxygenase (5-LOX)-catalyzed leukotriene (LT) production and β-hexosaminidase release in rat basophilic leukemia cells at 1-10 µM concentrations, indicating anti-allergic potential.
  2. 02 Dose-dependent inhibition of lipid droplet formation and adipocyte differentiation in OP9 cells, primarily during early adipogenesis, via downregulation of PPARγ and related genes, using a 70% ethanol extract.

Transparency

Not commonly dusted

Information regarding dusting practices for Alisma Orientale Extract is not available in the provided research data.


The Formula

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Optimal pH range for stability is not explicitly available in the provided search results.


Safety

CIR Status
Not reviewed
Sensitization risk Low

Alismatis rhizoma extracts are considered generally safe and well tolerated based on extensive traditional use and animal toxicity studies for oral administration. A 90-day repeated oral dose toxicity study of an aqueous extract in rats showed no signs of toxicity or mortality up to 2,000 mg/kg/day, establishing a no-observed-adverse-effect level (NOAEL) greater than 2,000 mg/kg/day. Acute oral toxicity (LD50 > 4,000 mg/kg) and repeated dose oral toxicity (LD50 > 2,000 mg/kg) studies in SD rats also support its safety for oral routes. Maximum concentration for topical cosmetic use is not yet established by regulatory bodies.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

Alisma Orientale Extract is a valuable botanical ingredient, offering comprehensive benefits including antioxidant protection, significant anti-inflammatory and anti-allergenic effects, and skin oil balance, with a low risk of irritation and broad skin type compatibility.


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