Science
Mechanism of Action
This ingredient operates via a dual mechanism. The aluminum component provides an astringent effect by promoting the contraction of skin cells and tissues, which effectively reduces sweat diffusion, tightens the skin, minimizes oiliness, and refines pore appearance. Concurrently, the allantoin moiety actively minimizes irritation, accelerates the proliferation of epithelial cells, and supports the regeneration of damaged tissue, aiding in the removal of necrotic material. ALCLOXA further exhibits bacteriostatic effects, particularly against Gram-positive bacteria, by modulating the local pH and through the inherent antimicrobial action of its aluminum salt, while also contributing to skin hydration by enhancing the water content within the extracellular matrix.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Demonstrated effective antiperspirant and deodorant action in axillae, inhibiting odor formation and bacterial decomposition, with no primary irritation or sensitization reported even after prolonged use, and favorable reports from sensitive individuals.
- 02 Recommended for anti-acne products to promote the healing of pustules and oozing lesions, reduce infected skin eruptions, and provide a soothing action, often in combination with antimicrobial agents.
- 03 Supports regeneration of surface lesions and soothes shaving irritations when incorporated into shave products.
- 04 Exhibited bacteriostatic effects in vitro against S. aureus and Pityrosporum ovale, with notable inhibition zones.
Transparency
Dusting Analysis
ALCLOXA is recognized for its efficacy at concentrations up to 2.0%, supported by FDA approval for certain Over-the-Counter (OTC) applications within this range. Its demonstrated benefits are achieved at these active dosages, indicating it is not typically 'dusted' in formulations.
The Formula
Formulation
Stability
ALCLOXA is stable across a broad pH range of 3.0-8.0 and withstands processing temperatures up to 80°C. A 1% aqueous solution typically presents a pH between 4.0-5.0. To maintain stability and prevent hydrolysis, moisture contamination must be avoided during synthesis and handling.
Synergies
- Enhanced efficacy in anti-acne formulations when combined with other antimicrobial agents.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has deferred evaluation as its safety has been assessed by the FDA, permitting its use as an active ingredient in OTC anorectal drug products as a keratolytic agent at 0.2% to 2.0%. Extensive preliminary animal and human usage tests indicate it is non-sensitizing and non-irritating, even at a 25% suspension. While the powder form can be an eye irritant, a 10% aqueous solution was not irritating, generally affirming its safety for topical cosmetic application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
ALCLOXA is a valuable multifunctional ingredient, offering robust astringent, antimicrobial, soothing, and healing properties with a low irritation risk, making it suitable for a broad spectrum of skin conditions and compatible with all skin types.
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