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ALCHEMILLA VULGARIS LEAF EXTRACT.

Valuable CAS 84695-94-3 / ANTIOXIDANT, ASTRINGENT, SKIN CONDITIONING

Alchemilla Vulgaris Leaf Extract, derived from Lady's Mantle, is a multifaceted botanical celebrated for its potent antioxidant, anti-inflammatory, and astringent properties. It actively protects skin from environmental stressors, calms irritation, refines pores, and significantly supports overall skin regeneration and elasticity. This versatile extract contributes to a visibly healthier and more resilient skin barrier.

Summary

Antioxidant Anti-inflammatory Astringent Skin Conditioning Skin Regenerating Wound Healing Support Collagen Support Barrier Strengthening Antimicrobial Skin Brightening

Science

Mechanism of Action

Alchemilla Vulgaris Leaf Extract functions through several key mechanisms to enhance skin health. Its rich composition of flavonoids, phenolic acids, and tannins provides robust antioxidant defense, safeguarding the skin from free radical damage and mitigating signs of premature aging. The extract also demonstrates anti-inflammatory capabilities, effectively reducing irritation and soothing the skin, which is particularly beneficial for conditions like eczema, psoriasis, and acne. As a natural astringent, it aids in skin cleansing, pore tightening, and regulating sebum production. Furthermore, it promotes skin regeneration, supports wound healing, and stimulates collagen turnover, contributing to improved skin elasticity, hydration, and the amelioration of stretch marks. It also reinforces the skin barrier and offers antimicrobial and tyrosinase inhibitory (skin brightening) properties.

Research

Clinical Evidence

Medium confidence
Effective range 2–5%
Optimal

2-5%

Key findings

  1. 01 In-vitro studies demonstrated a significant increase in cell proliferation, specifically 21.3% in MDBK cells, 15.5% in myofibroblasts, and 10.6% in Chang liver cells.
  2. 02 An in-vivo animal study on rats observed a 10.07% reduction in lesion diameter after 2 days and a 23.2% reduction after 3 days.
  3. 03 A human in-vivo double-blind randomized study revealed that creams containing the extract produced a significant anti-irritant effect on artificially irritated skin.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Alchemilla Vulgaris Leaf Extract exhibits a favorable safety profile and is generally well-tolerated across diverse skin types. While rare instances of allergic reactions or skin sensitivity may occur, especially in individuals with pre-existing sensitivities, a patch test is recommended for such cases. No known toxic effects have been associated with Herba Alchemillae, and EWG Skin Deep assessments indicate a low concern for common toxicological risks.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Alchemilla Vulgaris Leaf Extract is a valuable botanical ingredient offering robust antioxidant, anti-inflammatory, and skin regenerating benefits, supported by human clinical data for its anti-irritant effects.

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