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ALCHEMILLA VULGARIS EXTRACT.

Valuable CAS 84695-94-3 / ASTRINGENT, SKIN CONDITIONING

Alchemilla Vulgaris Extract, derived from Lady's Mantle, is a multifaceted botanical ingredient celebrated for its potent antioxidant, anti-inflammatory, and astringent properties. It actively promotes skin regeneration, supports elasticity, and contributes to a firmer, more even-toned complexion, addressing a wide spectrum of skin concerns.

Summary

Antioxidant Skin-conditioning Soothing Astringent Anti-inflammatory Skin Regeneration Wound Healing Support Collagen Turnover Support Skin Barrier Fortification Oil Regulation Antibacterial Skin Brightening (Tyrosinase Inhibitory)

Science

Mechanism of Action

This extract functions as a robust antioxidant, diligently protecting the skin from oxidative damage caused by free radicals. Its anti-inflammatory and soothing capabilities help calm irritation, making it beneficial for conditions such as eczema, psoriasis, and acne. The inherent astringent qualities, primarily attributed to tannins, aid in skin cleansing, pore refinement, and imparting a perceptibly firmer appearance. Moreover, Alchemilla Vulgaris Extract supports skin's natural regenerative processes, facilitating wound healing, enhancing collagen turnover, and promoting skin tissue regeneration. It assists in maintaining the integrity of the skin barrier, crucial for preserving elasticity and hydration, while also contributing to balanced oil production. Further benefits include antibacterial activity and tyrosinase inhibitory effects, which can aid in addressing hyperpigmentation.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–3%
Optimal

N/A

Key findings

  1. 01 An in vitro study demonstrated increased cell proliferation: 21.3% in MDBK cells, 15.5% in myofibroblast cells, and 10.6% in Chang liver cells, indicating regenerative potential.
  2. 02 In a rat model, topical application led to a significant reduction in lesion diameter by 10.07% after 2 days and 23.2% after 3 days.
  3. 03 In vitro studies identified these as the IC50 doses for inhibiting melanoma cell viability.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Conflicts

  • High concentrations of tannins within the extract pose a potential risk of denaturing skin proteins if the extract is not adequately processed to reduce or remove high tannin levels.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Alchemilla Vulgaris Extract is generally considered to have a favorable safety profile and complies with European standards for cosmetic ingredients. However, as a natural botanical, rare instances of allergic reactions or skin sensitivity may occur, particularly due to its tannin content. Individuals with sensitive skin are advised to perform a patch test prior to widespread use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Alchemilla Vulgaris Extract is a valuable botanical ingredient offering a broad spectrum of benefits, from antioxidant protection and anti-inflammatory action to skin regeneration and pore refinement, making it a versatile addition to many skincare regimens.

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