Science
Mechanism of Action
This dipeptide acts as a precursor to glutathione, enabling potent antioxidant defense against free radicals, oxidative stress, and inflammation. It is a fundamental component for synthesizing structural proteins like collagen and elastin, thereby improving skin firmness and elasticity. Alanyl Glutamine also enhances skin hydration by boosting Natural Moisturizing Factors (NMFs) and promoting cellular water retention via aquaporin-3 (AQP-3) expression, reducing transepidermal water loss. Furthermore, it aids in tissue repair and possesses anti-inflammatory properties, stimulating glycosaminoglycans (GAGs) like hyaluronic acid for structural support and moisture.
Research
Clinical Evidence
Medium confidence2%
Key findings
- 01 Topical application between 0.5% and 3% concentration may aid in wound healing, reduce inflammation, support collagen synthesis, maintain skin moisture, and improve skin barrier function. A 2% concentration is recommended for skincare products.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
A hygroscopic, white crystalline powder, Alanyl Glutamine is susceptible to degradation above 40°C through amide bond cleavage, cyclic amino acid formation, and isomer impurities. It requires storage away from direct sunlight and heat, ideally refrigerated (5-8°C) for long-term stability.
Conflicts
- High temperatures (above 40°C)
- Direct sunlight
Safety
Safety Profile
Alanyl Glutamine is generally considered safe for topical cosmetic use. EWG Skin Deep rates it as 'LOW' for potential health concerns, and it has no reported side effects when applied to the skin, making it suitable for all skin types.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Alanyl Glutamine is a valuable ingredient for comprehensive skin health, offering significant benefits in hydration, antioxidant protection, and barrier repair, suitable for a wide range of skin types.
Related
Similar Ingredients
Finding similar ingredients…