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Moumoujus

ALANGIUM SALVIIFOLIUM BARK EXTRACT.

Insufficient Data / SKIN CONDITIONING

Alangium Salviifolium Bark Extract is a botanical ingredient derived from the bark of the Alangium salvifolium plant, exhibiting a spectrum of activities beneficial for skin health. Research indicates its potential for anti-inflammatory, antimicrobial, and antioxidant effects, alongside promising wound healing and antiproliferative properties.

Summary

Skin Conditioning Antioxidant Anti-inflammatory Antimicrobial Wound Healing

Science

Mechanism of Action

This extract leverages a rich profile of phytochemicals, including alkaloids, flavonoids, saponins, phenols, glycosides, tannins, steroids, and terpenoids, to exert its effects. It primarily functions by reducing inflammatory responses, scavenging free radicals through its antioxidant components, and demonstrating broad-spectrum antimicrobial action against bacteria, fungi, and yeast. Furthermore, it has shown activity in promoting wound healing and inducing antiproliferative and apoptotic effects in skin cancer cell lines.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated anti-inflammatory activity in rats, with an ethanolic extract showing 36.84% to 65.53% inhibition of paw volume at doses of 500 mg/kg over 1 to 4 hours.
  2. 02 Exhibited antiproliferative and apoptotic activities on A431 (epidermoid carcinoma) and B16F10 (melanoma) skin cancer cells in a dose-dependent manner (methanolic bark extract).
  3. 03 Possesses wound healing properties and antimicrobial activity against various strains of bacteria, fungi, and yeast, attributed to its diverse phytochemical composition.
  4. 04 Contains antioxidant components, such as flavonoids and phenolic compounds, contributing to its free radical scavenging capabilities.

Transparency

Dusting Analysis

Not commonly dusted

No data available regarding dusting practices or specific concentration thresholds for this ingredient in cosmetic formulations.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The presence of compounds extractable by various solvents (aqueous, methanol, ethanol, chloroform, hexane, ethyl acetate) suggests a diverse chemical profile with components exhibiting both water and oil solubility. Specific stability parameters or optimal pH ranges for cosmetic formulation are not yet established.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments by the CIR or SCCS have been identified. A sub-chronic safety evaluation of an aqueous extract of Alangium salvifolium leaves in rats (up to 400 mg/kg) indicated no significant toxicological effects on most parameters, though further chronic toxicity studies were recommended. The ingredient is listed with FDA UNII P00V832S8X.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

ALANGIUM SALVIIFOLIUM BARK EXTRACT presents intriguing in vitro and animal study results for anti-inflammatory, antioxidant, antimicrobial, and skin cancer cell-inhibiting activities, but lacks sufficient human clinical data for a definitive cosmetic efficacy and safety profile.

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