Science
Mechanism of Action
Teupolioside, its key active, exhibits potent antioxidant activity by scavenging ROS and inhibits 5-alpha-reductase to regulate sebum production. It also reduces inflammation by suppressing pro-inflammatory mediators like TNF-alpha and supports collagen and elastin integrity.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Topical application (0.5-2%) demonstrated significant reduction in sebum levels and anti-inflammatory effects in acne-prone skin. It increased skin hydration by 8.3% and elasticity by 9.0% when in O/W emulsions.
- 02 A 1% formulation clinically reduced pore visibility by 21.6% and hyperpigmentation by 9.8% after 4 weeks of use.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Highly stable in aqueous O/W emulsions within physiological pH range. Phenylpropanoid content is sensitive to heat; add during the cool-down phase (<40°C) of production.
Conflicts
- Strong oxidizing agents
- Extreme pH (<3.0 or >8.0)
Safety
Safety Profile
While not CIR-reviewed as a standalone cell culture, the genus Ajuga and its primary metabolite Teupolioside have extensive safety data. Dermatological patch tests showed no irritation (mean index of 0).
Your Skin
Skin Compatibility
Our Assessment
Verdict
Ajuga Reptans Meristem Cell Culture is a valuable, evidence-backed ingredient for addressing sebum, inflammation, pore visibility, and overall skin health with demonstrated improvements in hydration and elasticity.
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References
Sources