Science
Mechanism of Action
This extract reduces pro-inflammatory cytokines, scavenges radicals, and promotes extracellular matrix deposition crucial for wound repair. Its tannin content also provides astringent and antimicrobial properties.
Research
Clinical Evidence
High confidence10% w/v
Key findings
- 01 Topical application of 10% w/v extract three times daily significantly improved open and sutured wound healing in vivo, increasing wound tensile strength and contraction rates.
- 02 A 10% w/v extract shortened wound healing time to 10-16 days in rat models, whereas 1% w/v showed no remarkable activity.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Active polyphenols are sensitive to high heat, with stability best maintained below 60°C. Stability can be improved via cyclodextrin inclusion complexes.
Conflicts
- strong oxidizers
- heavy metal salts
Safety
Safety Profile
Recognized by the EMA for traditional use in minor skin inflammations. Toxicity is observed only at high concentrations (100-1000 mg/L) in cell cultures, but potential for photosensitivity has been noted.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Valuable for targeted skin repair and anti-inflammatory formulations, particularly at a 10% concentration for proven wound healing benefits.
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