Science
Mechanism of Action
Its efficacy stems from high concentrations of tannins and flavonoids, which scavenge free radicals and inhibit pro-inflammatory cytokines. It further induces fibroblast-to-myofibroblast conversion, enhancing ECM deposition and accelerating healing.
Research
Clinical Evidence
High confidence10%
Key findings
- 01 Topical 10% aqueous extract reduced rat wound healing time to 12 days versus 16+ days for control, promoting fibroblast conversion and ECM.
- 02 Topical 10% ethanolic extract in ointment accelerated rat wound healing to 10 days, outperforming both aqueous extract and a standard antibiotic.
- 03 In vitro, 1% extract enhanced proliferation and differentiation of human dermal fibroblasts and keratinocytes, supporting acute wound treatment.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
For optimal stability, store in airtight, light-protected containers to prevent polyphenol oxidation. Integrate during cool-down phases of emulsions.
Conflicts
- strong oxidizers
- iron salts (may cause color change)
- highly alkaline environments (degrades flavonoids)
Safety
Safety Profile
Recognized by the EMA for minor skin inflammation and classified as safe (Class 1) by AHPA. A botanical ingredient, potential for photodermatitis exists.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This valuable botanical active is clinically validated to accelerate wound healing, reduce inflammation, and support skin regeneration for all skin types.
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References
Sources