Science
Mechanism of Action
This extract functions by neutralizing reactive oxygen species and inhibiting pro-inflammatory cytokines, bolstering cellular defense. On the skin, it notably stimulates fibroblast proliferation and enhances extracellular matrix deposition, especially collagen-3, while tannins provide tightening and sebum-regulating effects.
Research
Clinical Evidence
Medium confidence10%
Key findings
- 01 In rat models, 10% topical aqueous extract significantly improved wound healing, increasing tensile strength and contraction rates, whereas 1% was ineffective.
- 02 Separately, a 10% ethanolic extract ointment shortened wound healing time to 10-16 days compared to controls.
- 03 In vitro, human dermal fibroblasts showed enhanced ECM deposition and proliferation at concentrations as low as approximately 0.0039%.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Rich in polyphenols and tannins, the extract is susceptible to oxidation and light, necessitating dark glass storage. Optimal stability is achieved within slightly acidic pH ranges, typically between 4.5 and 5.5.
Conflicts
- Strong oxidizers
- Iron salts (may cause darkening/discoloration)
- Gelatin
- Strongly alkaline environments (pH > 8.0)
Safety
Safety Profile
While not reviewed by the CIR Panel, the EMA acknowledges its traditional topical use. It contains photosensitizing compounds that may induce photodermatitis in some individuals, yet acute toxicity studies generally classify it as non-toxic (LD50 > 2500 mg/kg in rats).
Your Skin
Skin Compatibility
Our Assessment
Verdict
Agrimonia Eupatoria Extract is a valuable botanical offering antioxidant, anti-inflammatory, and astringent benefits, with demonstrated efficacy in wound healing and ECM support for diverse skin types.
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References
Sources