Science
Mechanism of Action
This extract acts as a humectant by drawing water to the stratum corneum via fructans and fructo-oligosaccharides. It strengthens the skin barrier by stimulating epidermal differentiation proteins and offers anti-inflammatory benefits through steroidal saponins.
Research
Clinical Evidence
Medium confidence10%
Key findings
- 01 In vivo animal models showed 5-10% concentrations significantly improved wound healing, with 10% demonstrating epithelialization comparable to antibiotic ointment and increased tensile strength from Day 4.
- 02 In vitro studies showed 2.5-10 mg/mL concentrations exhibited antibacterial activity against S. aureus, P. aeruginosa, and S. typhi, comparable to Gentamycin.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Heat-stable up to moderate temperatures, it should be incorporated during the cooling phase (<40°C) to protect delicate phytochemicals. It's often supplied in a glycerin/water base.
Conflicts
- Strong oxidizing agents
- Extremely low pH (<3.5) may cause hydrolysis of polysaccharides
Safety
Safety Profile
While CIR has not formally reviewed it, the ingredient is generally considered safe in finished cosmetic formulations. Fresh plant sap is an irritant due to calcium oxalate crystals, but these are typically removed during commercial extraction.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Agave Americana Stem Extract is a valuable ingredient for hydration, barrier support, and soothing, compatible with all skin types and offering low irritancy.
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References
Sources