Science
Mechanism of Action
It primarily inhibits inflammatory mediators (iNOS, ROS) and upregulates critical barrier proteins such as filaggrin and involucrin, enhancing natural moisturizing factors. Additionally, it protects collagen and elastin by inhibiting elastase, hyaluronidase, and MMP activities.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Topical application effectively reduced skin burning and stinging, accelerated barrier repair, and decreased TEWL and erythema in sensitive skin.
- 02 Showed strong synergistic effects in protecting Hs68 cells from UVB-induced photoaging, increasing collagen and reducing MMP production.
- 03 Significantly upregulated filaggrin (6.0-fold) and caspase-14 activity (1.8-fold) in UV-B irradiated keratinocytes, demonstrating barrier and anti-inflammatory benefits.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Contains heat-labile polyphenols, preferring low-temperature extraction (60°C) for optimal potency. Stable at room temperature for 12 weeks in gel formulations, with slight antioxidant degradation at 40°C.
Synergies
- Nicotinamide (enhanced photoaging protection, collagen production)
Conflicts
- Strong oxidizing agents
- Highly alkaline environments (risk of phenolic oxidation/discoloration)
Safety
Safety Profile
While not CIR-reviewed, it's widely used in K-beauty and FDA-reviewed as a New Dietary Ingredient. Cosmetic concentrations typically range from 0.1% to 3.0%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Agastache Rugosa Extract is a valuable active for comprehensive skincare, offering significant benefits in soothing sensitive skin, strengthening the barrier, and providing anti-aging protection.
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References
Sources