Science
Mechanism of Action
It acts as an antioxidant by reducing ROS and upregulating protective enzymes, while inhibiting MMPs to prevent collagen degradation. Additionally, it suppresses pro-inflammatory cytokines, driven by key actives like rosmarinic acid and tilianin.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Concentrations of 0.1-2.0% (extract) demonstrate anti-photoaging effects by reducing ROS, inactivating MAPK/AP-1 pathways, and downregulating MMPs.
- 02 In vitro, 10-20 μg/mL promoted type-I procollagen production and suppressed inflammatory cytokines (IL-1β, IL-6, IL-8).
- 03 At 131.16 ppm, it provided 80% human dermal fibroblast survival against UVB radiation; synergistic effects were observed with Nicotinamide at 17.50 ppm.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Maintains neutral pH upon extraction and is rich in water-soluble phenolics like rosmarinic acid. Its production via plant cell culture enhances stability compared to traditional plant extracts.
Synergies
- Nicotinamide (NAM)
Conflicts
- Strong oxidizing agents
- Extreme pH environments (below 4 or above 8)
Safety
Safety Profile
While not CIR reviewed as of 2024, the parent plant is widely used in traditional medicine. The callus culture method ensures a clean ingredient, free from common contaminants like pesticides and heavy metals.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This potent plant cell culture offers significant antioxidant, anti-inflammatory, and photoaging protection, making it a valuable asset for diverse skin concerns.
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References
Sources