Science
Mechanism of Action
It stimulates fibroblast activity to boost collagen and elastin synthesis, while activating the Keap-1-Nrf2/ARE pathway for enhanced antioxidant defense. The extract also inhibits MMP-1 and MMP-9 enzymes, which are responsible for collagen degradation.
Research
Clinical Evidence
High confidence0.08%
Key findings
- 01 Polysaccharides at 800 μg/mL significantly accelerated collagen (COL-I) and elastin (ELN) synthesis, while decreasing MMP-1 and MMP-9, demonstrating anti-photoaging effects.
- 02 Extract concentrations up to 100 µg/mL showed no cytotoxicity in keratinocyte cell viability models, confirming safety for topical use.
- 03 Higher concentrations (1 mg/mL and above) resulted in up to a 30% reduction in cell viability, indicating an upper safety threshold.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Highly stable in aqueous solutions, with heat-stable polysaccharides. Ensure proper preservation and avoid prolonged high-oxygen exposure to prevent polysaccharide degradation.
Conflicts
- Strong oxidizing agents
- High concentrations of alcohol (may cause polysaccharide precipitation)
- Strongly acidic environments (pH < 3.0)
Safety
Safety Profile
While not formally reviewed by the CIR, related mushroom polysaccharides are generally considered safe. Topical concentrations should not exceed 1.0% due to observed in vitro cytotoxicity at higher levels.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This extract is a valuable ingredient, effectively combating photoaging, enhancing antioxidant defenses, and promoting overall skin health through collagen stimulation and immunomodulation.
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References
Sources