Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

ADENOSINE PHOSPHATE.

Valuable CAS 61-19-8 / SKIN CONDITIONING

Adenosine Phosphate is a foundational cell-communicating ingredient vital for optimized skin function. It targets cellular processes to enhance skin firmness, reduce visible signs of aging, and promote overall regeneration through improved cellular energy and signaling.

Summary

skin conditioning anti-aging wound healing anti-inflammatory collagen booster elastin booster barrier repair cell-communicating ingredient

Science

Mechanism of Action

Functioning within the adenosine family, Adenosine Phosphate actively engages specific A1 and A2A receptors within the skin, stimulating key dermal processes. It effectively boosts the synthesis of new DNA, proteins, collagen, and elastin, which collectively diminishes the appearance of wrinkles and fine lines and confers a firming effect. Furthermore, it demonstrates anti-inflammatory capabilities by modulating immune responses from immune cells like neutrophils and macrophages, thereby aiding in tissue repair and wound healing. As an essential cellular energy precursor, Adenosine Triphosphate (ATP), it invigorates fibroblast activity and cellular metabolism, crucial for sustained collagen production, revitalization, and comprehensive skin regeneration.

Research

Clinical Evidence

Medium confidence
Effective range ≤0.1%
Optimal

N/A

Key findings

  1. 01 Adenosine has been shown to increase cell proliferation at wound sites and accelerate endothelial cell wound healing.
  2. 02 In human participants, an Adenosine Triphosphate complex significantly increased mRNA expression of collagen and elastin, promoting wound healing and improving skin radiance, elasticity, and texture by boosting hyaluronan synthases.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

For the related Adenosine Triphosphate, maintaining a pH between 6.8 and 7.4 is suggested, and exposure to temperatures exceeding 40°C should be avoided to ensure stability.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
1%
Sensitization risk Low

The Cosmetic Ingredient Review Expert Panel has concluded that Adenosine Phosphate, along with other adenosine compounds, is safe for use in cosmetics at concentrations up to 1% in leave-on body and hand products. The FDA and European Medicines Agency (EMA) have approved adenosine-containing products for skin formulations at concentrations up to 0.1%. While certain drug applications of adenosine phosphates were withdrawn from the market due to a lack of safety or efficacy for those specific drug indications, cosmetic use of adenosine ingredients is unrestricted in the European Union.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Adenosine Phosphate is a valuable active ingredient for comprehensive skin rejuvenation, effectively targeting aging concerns, promoting barrier health, and accelerating wound repair across all skin types.

Related

Similar Ingredients

Finding similar ingredients…