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Moumoujus

ADENOSINE CYCLIC PHOSPHATE.

Avoid CAS 60-92-4 / SKIN CONDITIONING

Adenosine Cyclic Phosphate, also known as cAMP, functions as a critical intracellular second messenger, converting external cellular signals into a diverse array of internal responses. While theoretically offering anti-inflammatory and collagen-supporting benefits, its direct application in skincare is severely cautioned due to significant irritancy risks.

Summary

Anti-inflammatory Anti-aging (collagen support) Cellular communication Wound healing support

Science

Mechanism of Action

As a ubiquitous second messenger, Cyclic Adenosine Monophosphate (cAMP) mediates cellular communication by converting extracellular signals into intracellular responses. Its synthesis is initiated by adenylate cyclase (ADCY) upon external stimuli, leading to the activation of protein kinase A (PKA), which in turn phosphorylates various target proteins. In the skin, cAMP influences cellular proliferation, differentiation, and gene expression, notably inducing anti-inflammatory gene expression in immune cells while suppressing pro-inflammatory pathways. It also contributes to cytoskeleton dynamics, cell adhesion, and cell migration, which are vital for processes like wound healing. Adenosine, a precursor, further supports collagen production and cellular synthesis.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Elevated cyclic AMP levels may help mitigate inflammation and itchiness, symptoms frequently observed in conditions such as atopic dermatitis.
  2. 02 Enhancement of cyclic AMP has demonstrated an ability to reduce glucocorticoid response element activity and reverse collagen loss in Hs68 dermal fibroblast cells exposed to dexamethasone, suggesting a role in addressing collagen reduction associated with skin aging.
  3. 03 Cyclic AMP holds recognized therapeutic potential for various skin-related conditions, including the inhibition of melanoma cell proliferation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Insufficient data | not reviewed
Sensitization risk High

While the CIR Expert Panel deemed broader 'Adenosine Ingredients' generally safe at specified concentrations (e.g., Adenosine up to 1%), Adenosine Cyclic Phosphate specifically carries significant hazard warnings. PubChem lists GHS classifications indicating it 'Causes skin irritation' (H315), 'Causes serious eye irritation' (H319), and 'May cause respiratory irritation' (H335). Furthermore, a Safety Data Sheet for Adenosine, cyclic 3',5'-(hydrogen phosphate) classifies it as 'Skin Corrosion/Irritation; Category 1B', stating it 'Causes burns' upon skin contact. These severe warnings contradict a general 'safe as used' conclusion for this exact compound without specific cosmetic safety data. FDA has also withdrawn drug products containing related Adenosine compounds due to efficacy and safety findings, though this is distinct from cosmetic application.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its fundamental biological role and theoretical benefits in mitigating inflammation and collagen loss, Adenosine Cyclic Phosphate poses a severe risk of skin irritation and corrosion, making it unsuitable for cosmetic formulation.

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