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ADENOPHORA STRICTA ROOT EXTRACT.

Valuable / HUMECTANT, SKIN CONDITIONING

Adenophora Stricta Root Extract is a multi-functional botanical ingredient demonstrating potent antioxidant, anti-photoaging, and anti-inflammatory properties. It actively protects skin from environmental damage, improves skin tone uniformity, and supports overall skin health, making it a versatile asset for comprehensive skincare formulations.

Summary

Antioxidant Anti-inflammatory Anti-photoaging Skin Brightening Photoprotective Moisturizer/Humectant Skin Conditioning

Science

Mechanism of Action

This extract functions as a powerful antioxidant by significantly reducing reactive oxygen species (ROS) production, thereby mitigating oxidative stress. Its anti-photoaging efficacy stems from inhibiting elastase and matrix metalloproteinase-1 (MMP-1) activity at both mRNA and protein levels, which helps preserve collagen content. For skin brightening, it directly inhibits tyrosinase activity. Furthermore, it exerts anti-inflammatory actions by decreasing inflammatory cell infiltration and suppressing key proinflammatory cytokines (e.g., IL-4, TNF-α) and signaling pathways (JNK, IKKα/β, p65 phosphorylation), while also offering photo-protective benefits against UVB-modulated damage. It also acts as a moisturizer and skin conditioning agent.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro and animal studies indicate that Adenophora Stricta Root Extract significantly attenuates reactive oxygen species (ROS) production, inhibits elastase activity and matrix metalloproteinase-1 (MMP-1) at both mRNA and protein levels, and helps preserve collagen content, suggesting a potential role in preventing and treating skin photoaging. It may also act as a photo-protective agent by inhibiting UVB-modulated signaling pathways.
  2. 02 Additionally, Adenophora Stricta Root Extract demonstrates a skin whitening effect by inhibiting tyrosinase activity.
  3. 03 Animal studies (oral administration in mice at 100-400 mg/kg) have shown dose-dependent anti-inflammatory effects, including reducing inflammatory cell infiltration, decreasing proinflammatory cytokines (e.g., IL-4, IL-5, TNF-α, IL-1β, IL-6, and MCP-1), and inhibiting key signaling pathways like c-jun N-terminal kinase (JNK), inhibitory-κB kinase α/β (IKKα/β), and p65 phosphorylation.

Transparency

Dusting Analysis

Not commonly dusted

There is no available data to suggest that Adenophora Stricta Root Extract is commonly included in formulations at concentrations too low to be effective, or that it is used for "dusting" purposes.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Formal safety assessments by regulatory bodies such as CIR, SCCS, or FDA are not available for this ingredient, with general toxicity data listed as 'Not determined'. However, EWG Skin Deep indicates a low concern for cancer, allergies & immunotoxicity, developmental and reproductive toxicity, and use restrictions, suggesting a favorable safety profile based on current available data.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Adenophora Stricta Root Extract is a valuable botanical offering comprehensive antioxidant, anti-inflammatory, anti-aging, and brightening benefits suitable for all skin types, with a low perceived risk profile.

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