Science
Mechanism of Action
This extract exerts its anti-inflammatory effects by inhibiting vascular permeability and reducing edema, a process supported by its identified role as a plasmin inhibitor. Its robust antioxidant capacity stems from its ability to scavenge reactive oxygen species (ROS), inhibit DPPH and nitric oxide, and demonstrate reducing power, primarily attributed to its high content of phenolic and flavonoidal compounds. Furthermore, it demonstrates broad-spectrum antimicrobial activity against both Gram-positive (e.g., B. subtilis, S. epidermidis) and Gram-negative bacteria (e.g., E. aerogenes, P. aeruginosa, S. typhimurium). Preliminary research suggests potential protection against damaging UV-A, UV-B, and LR rays that contribute to skin aging and wrinkling.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Oral administration of 50-200 mg/kg body weight of seed extract in rats and mice significantly inhibited carrageenan-induced paw edema and acetic-acid-induced vascular permeability, demonstrating anti-inflammatory properties.
- 02 An ethanolic leaf extract at 100 mg/kg body weight (oral) achieved a high efficacy of 91.27% in reducing carrageenan-induced rat hind paw edema.
- 03 Bark extracts applied at 25, 50, and 75 mg/well exhibited effective antimicrobial activity against a range of Gram-positive and Gram-negative bacteria, measured by inhibition zones.
- 04 Oral doses of 50-200 mg/kg body weight demonstrated dose-dependent analgesic activity in mice using acetic-acid-induced writhing and formalin-induced paw licking tests.
Transparency
Dusting Analysis
Information regarding the 'dusting' phenomenon or specific usage thresholds in cosmetic formulations is not available in the provided research data.
The Formula
Formulation
Stability
While specific pH stability data is not explicitly detailed, the use of various solvents (e.g., methanol, ethanol, water, hexane, ethyl acetate) for extraction indicates that the beneficial compounds within the extract demonstrate solubility across a range of polarities. Further stability testing would be required to define optimal pH conditions for specific cosmetic formulations.
Safety
Safety Profile
Acute toxicity studies in animals indicate a favorable safety profile, with ethanolic leaf extracts showing no toxicity up to 5000 mg/kg body weight and methanolic leaf extracts having an LD50 exceeding 8000 mg/kg. Another extract reported an LD50 of 1.36 g/kg. No specific Cosmetic Ingredient Review (CIR), Scientific Committee on Consumer Safety (SCCS), or FDA status for cosmetic use was found, and human topical safety data, including sensitization risk, are not detailed in the provided research.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Adenanthera pavonina Extract presents as a valuable multi-functional ingredient with scientifically supported anti-inflammatory, antioxidant, and antimicrobial properties, making it beneficial for diverse skin concerns from irritation to premature aging.
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