ACTAEA HERACLEIFOLIA ROOT EXTRACT.

Actaea Heracleifolia Root Extract functions as a powerful antioxidant by effectively scavenging free radicals, demonstrated by 99.6% ABTS and 94.2% DPPH scavenging activity. Its anti-inflammatory action involves a significant 55.3% reduction in TNF-α expression and near-complete suppression of nitric oxide production. The extract inhibits collagen degradation through a 43.0% reduction in elastase and an 89.1% decrease in hMMP-1 expression in HDF cells, while simultaneously promoting collagen production by increasing COL1. It also provides protection against UV-induced damage by modulating MAPK and AP-1 signaling pathways and reducing reactive oxygen species. Furthermore, it exhibits antibacterial activity, notably inhibiting *Staphylococcus aureus* growth by 43.5%. These effects are attributed, in part, to antioxidative flavonoid components like cyanidin-3-O-β-D-glycoside and taxifolin-7-O-glucoside.