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Moumoujus

ACORUS CALAMUS ROOT EXTRACT.

Valuable CAS 84775-39-3 / PERFUMING, SKIN CONDITIONING

Acorus Calamus Root Extract is a multi-functional botanical ingredient prized for its anti-inflammatory, antioxidant, and antimicrobial properties. It offers astringent benefits, helping to visibly tighten pores and balance sebum production in the skin.

Summary

soothing antioxidant antimicrobial perfuming

Science

Mechanism of Action

It significantly reduces pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α, while acting as an antioxidant through its phenolic and flavonoid compounds. Additionally, it promotes wound healing by upregulating VEGF and bFGF, modulating P53, Bax, and Bcl-2 proteins to inhibit apoptosis.

Research

Clinical Evidence

Medium confidence
Effective range 0.13–0.78%
Optimal

N/A

Key findings

  1. 01 In vitro risk modeling using SARA-ICE models identified 0.13-0.78% as conservative safe-use concentrations for leave-on products to avoid sensitization (NIH/MDPI 2024).
  2. 02 An alcoholic extract at 5.0% demonstrated significant antifungal activity against Candida albicans in a gel formulation, comparable to clotrimazole (Indo American Journal of Pharmaceutical Research 2016).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 6.8
0 7 14

Stability

The extract is typically stable across acidic to neutral pH ranges (4.0-6.8). It is often supplied as hydro-glycolic or alcoholic extracts, facilitating water dispersibility.

Conflicts

  • Strong oxidizing agents
  • High-heat processes

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.78%
Sensitization risk Moderate

Not reviewed by CIR. Classified as a GHS Category 1B skin sensitizer and Category 2 skin irritant; however, cosmetic-grade extracts are processed to be beta-asarone-free, mitigating potential carcinogenic concerns.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Medium
Comedogenicity Low

Our Assessment

Verdict

Valuable

Acorus Calamus Root Extract is a valuable botanical for its multi-faceted skin benefits, provided it is used within established safe concentrations to mitigate potential sensitization risks.

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