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Moumoujus

ACORUS CALAMUS ROOT.

Questionable CAS 84775-39-3 / SKIN CONDITIONING

Acorus Calamus Root extract offers potent antioxidant and anti-inflammatory benefits, promoting skin regeneration and soothing discomfort. It supports wound healing by boosting collagen production and reducing oxidative stress.

Summary

skin conditioning soothing perfuming antimicrobial antioxidant

Science

Mechanism of Action

It acts by inhibiting key inflammatory pathways (NF-κB, MAPK) and reducing pro-inflammatory cytokines, while boosting antioxidant enzyme activity. For dermal repair, it enhances fibroblast proliferation, angiogenesis, and collagen maturation.

Research

Clinical Evidence

Medium confidence
Effective range 0.13–7.46%
Optimal

0.78%

Key findings

  1. 01 A 70% ethanolic extract applied topically in rat models demonstrated enhanced wound contraction, increased collagen levels, and reduced oxidative damage.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 4 – 6.8
0 7 14

Stability

The extract is sensitive to light, heat, and oxidation, requiring stabilization through nano-encapsulation or incorporation into oil-based phases/emulsions. An optimal pH range for stability is generally 4.0-6.8.

Conflicts

  • strong oxidizing agents
  • aqueous-only systems without solubilizers

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.78%
Sensitization risk High

The FDA prohibits Calamus in food due to carcinogenic β-asarone, making β-asarone-free extracts critical for cosmetics. Safety modeling predicts it as a GHS Category 1B skin sensitizer, limiting leave-on use to 0.78% to avoid this risk.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Questionable

While offering antioxidant and anti-inflammatory properties, Acorus Calamus Root's predicted skin sensitization risk and concerns regarding β-asarone content make its inclusion questionable for precision skincare.

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