Science
Mechanism of Action
It exerts anti-inflammatory effects by inhibiting nitric oxide and interleukin-2 production, and its antimicrobial action stems from modulating bacterial membrane permeability. The extract acts as an antioxidant by scavenging free radicals and supports wound healing via collagen maturation.
Research
Clinical Evidence
Medium confidence0.78%
Key findings
- 01 Ethanolic rhizome extract accelerated wound healing by increasing collagen synthesis, hexosamine, and uronic acid levels, while significantly reducing lipid peroxide (antioxidant effect).
- 02 Quantitative risk modeling confirmed these concentrations as safe for leave-on products, minimizing sensitization risk.
- 03 Modeled as a safe concentration for rinse-off formulations based on non-animal methods for skin irritation and sensitization.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Bioactive compounds are sensitive to light and heat; nano-encapsulation or lipid-based delivery systems can enhance stability. It is often supplied in glycerin, water, or ethanol bases.
Conflicts
- Strong oxidizing agents
- Highly acidic environments
Safety
Safety Profile
The FDA prohibits its use in food due to β-asarone; β-asarone-free extracts are preferred in cosmetics. In concentrated oil form, it is classified as a GHS Category 1B skin sensitizer and Category 2 irritant.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Acorus Calamus Rhizome Extract is a valuable multi-functional ingredient, offering soothing, antioxidant, and antimicrobial benefits with documented wound healing properties, provided it is used within safe, low concentrations.
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References
Sources