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ACHYRANTHES JAPONICA ROOT/RHUS SEMIALATA GALL/TERMINALIA CHEBULA FRUIT/GLYCYRRHIZA URALENSIS ROOT/STEM EXTRACT.

Valuable / ANTIMICROBIAL

A multi-botanical complex, often known as AC-Zero, combining Achyranthes japonica, Rhus semialata, Terminalia chebula, and Glycyrrhiza uralensis. It is widely used in professional skincare to address concerns associated with acne-prone and oily skin.

Antimicrobial Soothing Antioxidant Sebum Regulation Pore Refining Skin Conditioning

Science

It targets acne through antimicrobial action against C. acnes and anti-inflammatory effects, particularly from Glycyrrhiza uralensis. The complex also regulates sebum production by inhibiting 5-alpha reductase and provides pore-tightening benefits.


Research

High confidence
Effective range 0.5–2%
Optimal

2%

Key findings

  1. 01 A 2.0% concentration significantly reduced sebum excretion and improved acne lesions (inflammatory and non-inflammatory) within 4 weeks. In vitro tests showed P. acnes inhibition and reduced 5-alpha reductase activity.
  2. 02 In vitro evaluations at 0.5% - 2.0% demonstrated strong antioxidant activity and anti-inflammatory effects by inhibiting nitric oxide production in LPS-stimulated macrophages.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

Sensitive to temperatures above 40-50°C and strong oxidizing agents. Tannins in the extract may lead to slight discoloration in clear formulations over time.

Conflicts

  • Strong oxidizing agents
  • Iron salts (may cause dark blue/black complexation with tannins)
  • Proteins/Gelatin (tannins can cause precipitation)

Safety

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

While the complex lacks CIR review, its individual components, such as Glycyrrhiza uralensis, are generally recognized as safe. High concentrations may impart a slightly drying effect due to tannin content.


Your Skin

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

This multi-botanical complex is a valuable asset for precision formulations targeting oily, acne-prone, and sensitive skin due to its proven efficacy in sebum regulation, antimicrobial, and anti-inflammatory actions.


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