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ACETYLSALICYLOYL PENTAPEPTIDE-33.

Valuable / ANTIOXIDANT, SKIN PROTECTING

A biomimetic conjugated peptide, Acetylsalicyloyl Pentapeptide-33 combines acetylsalicylic acid with Pentapeptide-33. It functions as a potent antioxidant and skin-protecting agent, specifically targeting photoaging.

Antioxidant Skin Protecting Anti-aging

Science

This peptide specifically inhibits the carbonylation of skin proteins, a key indicator of oxidative stress. It also reduces UV-induced pro-inflammatory cytokines, acting as a 'biological shield' to mitigate photoaging.


Research

High confidence
Effective range 0.001–0.5%
Optimal

N/A

Key findings

  1. 01 In-vivo studies demonstrated a 33% reduction in wrinkle depth and a 19% increase in skin elasticity over 28 days.
  2. 02 Acts as a targeted antioxidant, preventing protein carbonylation and lipid peroxidation caused by UV exposure.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 4 – 6.5
0 7 14

Stability

This peptide is sensitive to heat, requiring addition during the cool-down phase (<40°C). Optimal stability is achieved in aqueous formulations within a slightly acidic to neutral pH (4.0-6.5) to prevent hydrolysis.

Conflicts

  • Strong oxidizing agents
  • Strong acids or bases
  • Proteolytic enzymes

Safety

CIR Status
Not reviewed
Sensitization risk Low

The CIR has not independently reviewed this specific conjugate; however, it is listed in the EU CosIng database as an antioxidant and skin protectant. While a component, Salicylic Acid, is regulated, this peptide's regulatory status differs.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

This potent biomimetic peptide offers significant anti-aging and protective benefits against photoaging, suitable for all skin types.


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