Science
Mechanism of Action
This ingredient functions as an anti-aging signaling peptide by inhibiting the elastase enzyme, thus preventing the breakdown of elastin fibers. Additionally, it stimulates Type I collagen synthesis, which is crucial for restructuring connective tissue and boosting skin firmness.
Research
Clinical Evidence
Medium confidence4%
Key findings
- 01 An 8-week in-vivo study on mature women (average age 49) demonstrated a 14% improvement in skin elasticity and a 15.6% increase in skin tightness with twice-daily application.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Supplied as a solution in glycerin for enhanced stability and ease of handling. It remains stable within a broad physiological pH range, but should be incorporated into the aqueous phase of formulations at temperatures below 40°C.
Conflicts
- Strong oxidizing agents
- Strong acids/bases (risk of peptide hydrolysis)
- Proteolytic enzymes
Safety
Safety Profile
While not specifically reviewed by the CIR, this peptide is utilized in the industry at concentrations up to 4% and is generally considered non-irritating and safe for cosmetic topical use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This anti-aging tetrapeptide is a valuable ingredient, clinically shown to improve skin elasticity and tightness, with a favorable safety profile across all skin types.
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References
Sources