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ACETYL TETRAPEPTIDE-22.

Valuable CAS - / SKIN CONDITIONING

Acetyl Tetrapeptide-22 is a precision peptide engineered to enhance the skin's resilience against environmental stressors. It promotes cellular homeostasis and aids in the recovery of damaged proteins, making it beneficial for stressed or sensitive skin types.

Skin conditioning Soothing Stress tolerance enhancement Collagen stimulation Anti-inflammatory

Science

This peptide functions by inducing the expression of Heat Shock Protein 70 (HSP70), a molecular chaperone. HSP70 repairs damaged proteins and strengthens the skin's tolerance to environmental aggressors like UV radiation and temperature extremes, while also stimulating collagen and reducing inflammation.


Research

High confidence
Effective range 2–5%
Optimal

N/A

Key findings

  1. 01 In-vitro studies show a boost in Heat Shock Protein 70 (HSP70) levels, supporting damaged protein recovery and cellular homeostasis.
  2. 02 Recommended formulation use level to enhance skin's tolerance against temperature changes and UV-induced cellular stress.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 3 – 8
0 7 14

Stability

Highly stable in water-based systems, requiring storage at 2-8°C short-term or -20°C long-term, away from light.

Conflicts

  • Strong oxidizing agents
  • Strongly acidic conditions (< pH 3.0)
  • Strongly alkaline conditions (> pH 8.0)

Safety

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

Commonly used between 2% and 5% in finished formulations. Manufacturer safety assessments report it as non-irritating to skin and eyes.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Acetyl Tetrapeptide-22 is a valuable ingredient for enhancing skin's natural defense against environmental stressors and promoting repair across all skin types.


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