Science
Mechanism of Action
Mimicking thymopoietin, it stimulates Fibulin 5 and LOXL1 for proper elastic fiber assembly and induces Collagen I synthesis. The peptide also upregulates genes for focal adhesions, strengthening cellular connections to counteract skin laxity.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 An in vivo study at 2% concentration (solution) demonstrated a 25.2% decrease in maximal skin deformation, a 16% increase in general elasticity, and a 0.13 cm reduction in sagging over 56 days.
- 02 In vitro testing at 0.01 mg/ml showed a 2.3-fold increase in Fibulin 5 and a 1.7-fold increase in Lysyl Oxidase-Like 1, crucial for elastin.
Transparency
Dusting Analysis
Effective at very low concentrations of pure peptide (0.002-0.005%); significantly higher percentages of the pure peptide may not offer additional benefit beyond the optimal range.
The Formula
Formulation
Stability
Stable in water-based solutions but heat-sensitive. Add during the cooling phase (below 40-45°C) to protect peptide bonds.
Conflicts
- Strong oxidizing agents
- Strongly acidic environments (pH < 4.0)
- Strongly alkaline environments (pH > 8.0)
- Proteolytic enzymes
Safety
Safety Profile
Generally considered safe and non-irritating for cosmetic use. The max concentration refers to the pure peptide.
Your Skin
Skin Compatibility
Our Assessment
Verdict
ACETYL TETRAPEPTIDE-2 ACETATE is a valuable peptide for visibly improving skin elasticity and firmness, making it highly effective for targeted anti-aging formulations.
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References
Sources