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Moumoujus

ACETYL TETRAPEPTIDE-18.

Valuable CAS - / SKIN CONDITIONING

Acetyl Tetrapeptide-18 is a precision signal peptide that enhances skin firmness and reduces the appearance of fine lines. It improves extracellular matrix homeostasis and strengthens the skin barrier.

Summary

skin conditioning anti-aging collagen boosting firming barrier strengthening wrinkle reduction

Science

Mechanism of Action

This peptide mimics Activin-beta, inhibiting Matrix Metalloproteinase-3 (MMP-3) to prevent collagen degradation. Simultaneously, it stimulates the synthesis of Type III Collagen, a youthful collagen, restoring skin's structural integrity.

Research

Clinical Evidence

High confidence
Effective range 0.001–0.01%
Optimal

N/A

Key findings

  1. 01 In vitro studies show 0.001%-0.01% concentration inhibits MMP-3 and stimulates Type III Collagen, improving skin firmness.
  2. 02 Supports skin barrier and structural proteins to reduce fine lines and roughness, often synergized with colloidal gold for enhanced delivery.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

Stable in aqueous solutions; store cool and dark (2-8°C). Often formulated with colloidal gold to improve stability and delivery efficiency.

Synergies

  • Colloidal gold (enhances bioavailability and delivery)
  • Dipeptide-11 (for enhanced efficacy)

Conflicts

  • Strong oxidizing agents
  • Proteolytic enzymes
  • Extreme pH environments (below 4 or above 8)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Lacks formal CIR assessment, but is generally considered safe and non-irritating in typical cosmetic usage levels, typically under 1%.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Acetyl Tetrapeptide-18 is a valuable ingredient for targeting signs of aging by actively promoting youthful collagen synthesis and strengthening the skin barrier for improved firmness and reduced fine lines.

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