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ACETYL SH-TRIPEPTIDE-4 AMIDE.

Valuable / SKIN CONDITIONING

This biomimetic tripeptide offers significant anti-inflammatory and soothing benefits, effectively reducing skin redness and regulating sebum production. It also exhibits senolytic-like properties, targeting senescent cells for skin rejuvenation.

skin conditioning soothing anti-inflammatory sebum regulation anti-aging

Science

It functions as a CD99 antagonist, directly inhibiting pro-inflammatory cytokine release to calm irritation and regulate oil. Additionally, it helps eliminate aged 'zombie' cells, promoting a revitalized complexion.


Research

High confidence
Effective range 0.1–5%
Optimal

N/A

Key findings

  1. 01 Clinical evaluations using a supplier's raw material (Binterin Solution 400-W) showed significant anti-inflammatory and soothing effects, reduced sebum, and senolytic activity.

Transparency

Not commonly dusted

No specific data regarding 'dusting' behavior for this ingredient was provided in the research.


The Formula

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

Highly stable under harsh conditions, including temperatures up to 59°C. It is typically supplied in a water/glycol solution.

Conflicts

  • Strong oxidizing agents
  • High heat (>60°C) for prolonged periods
  • Extremely acidic or alkaline conditions (pH <4 or >8)

Safety

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

While not specifically reviewed by the CIR as a standalone ingredient, this synthetic tripeptide is generally recognized as safe for topical use up to 5% in solution. Studies on related acetylated tripeptides report no significant cytotoxicity or irritation.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

This multifaceted peptide is a valuable asset for addressing inflammation, sebum overproduction, and cellular aging across all skin types.


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