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ACETYL SH-PENTAPEPTIDE-1.

Valuable / SKIN CONDITIONING

ACETYL SH-PENTAPEPTIDE-1 is a stable, immunomodulating peptide that soothes irritation and preserves skin firmness. It enhances skin glow, elasticity, and refines pore texture.

cell-communicating ingredient skin conditioning soothing

Science

This acetylated Thymopoietin-mimetic peptide acts as an immunomodulator by suppressing pro-inflammatory IL-8 and reducing MMP-9 activity. This mechanism prevents Type IV Collagen degradation, maintaining basement membrane integrity and calming irritation.


Research

Medium confidence
Effective range 0.005–1%
Optimal

N/A

Key findings

  1. 01 As part of a multi-peptide complex, it was clinically proven to enhance facial glow, improve elasticity, and refine pore texture within 7 days.
  2. 02 Manufacturer data indicates significant reduction in IL-8 levels and MMP-9 activity, actively preserving Type IV Collagen.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

Acetylation improves stability in aqueous solutions. For emulsions, incorporate below 40°C during the cooling phase to maintain integrity.

Conflicts

  • Strong oxidizing agents
  • Proteolytic enzymes
  • Highly acidic (pH < 3.0) or highly alkaline (pH > 8.0) environments

Safety

CIR Status
Not reviewed
Sensitization risk Low

Generally regarded as safe for topical cosmetic use, with in vitro studies showing no cytotoxicity at standard formulation levels.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A valuable peptide for its robust immunomodulatory action, contributing to collagen preservation, soothing irritation, and visibly improving skin glow and elasticity.


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