Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle

ACETYL SH-OLIGOPEPTIDE-26 SH-OLIGOPEPTIDE-27 SP.

Valuable / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

This advanced peptide mimics Botox-like effects by reducing neurotransmitter exocytosis to diminish expression lines, while also offering a brightening effect through melanin transport inhibition.

Skin conditioning Emollient Skin protecting Anti-aging Anti-wrinkle Brightening Hyperpigmentation reduction

Science

Functioning as a cell-penetrating SNARE motif peptide, it inhibits SNARE complex formation, thereby preventing the release of neurotransmitters like norepinephrine and dopamine to relax facial muscles. It also precisely targets and inhibits melanin transport to keratinocytes.


Research

Medium confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

Stable in aqueous solutions within pH 5.0-7.0, but sensitive to extreme temperatures. Store cool to prevent denaturation.

Conflicts

  • Strong oxidizing agents
  • Strongly acidic environments (pH < 4.0)
  • Proteolytic enzymes

Safety

CIR Status
Not reviewed
Sensitization risk Low

In vitro tests on human dermal fibroblasts and B16-F10 cells showed no cytotoxicity, and reconstructed skin irritation tests confirmed it is non-irritating.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

This multifaceted peptide offers compelling anti-aging and brightening benefits by targeting both neurotransmitter release and melanin transport, with a favorable safety profile.


Related

Finding similar ingredients…