Science
Mechanism of Action
This peptide promotes the formation of the fibrillin-versican-hyaluronic acid complex, which anchors skin ligaments and strengthens structural integrity. It actively inhibits elastin-degrading enzymes (elastase, MMP-1/MMP-3) and stimulates new elastin and fibrillin-1 production.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 An in-vivo study with 30 volunteers using 1% concentration demonstrated an average 33% reduction in wrinkles and a 19% increase in skin elasticity within 28 days.
- 02 In-vitro and ex-vivo evaluations at 0.1% concentration showed up to 106% stimulation of elastin synthesis and a 32% improvement in skin density.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Highly stable in aqueous systems, this peptide should be incorporated during the final cooling phase of emulsions (below 40°C). Opaque, airtight packaging is recommended to minimize degradation from light and air.
Conflicts
- Strong oxidizing agents
- Highly acidic environments (pH < 3.0)
- Proteolytic enzymes
Safety
Safety Profile
While not individually reviewed by the CIR as of early 2024, supplier safety testing indicates it is non-irritating and non-sensitizing. Typical commercial usage is 1-3% of the solution.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Acetyl sh-Hexapeptide-5 Amide Acetate is a valuable biomimetic peptide, clinically proven to significantly enhance skin firmness and elasticity while maintaining excellent compatibility across all skin types.
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