Science
Mechanism of Action
This peptide mimics natural repair sequences, activating endogenous skin mechanisms to synthesize collagen and elastin. It strengthens the dermal matrix, enhances skin barrier function for improved moisture retention, and may inhibit pro-inflammatory cytokines when used synergistically.
Research
Clinical Evidence
Medium confidence3%
Key findings
- 01 Clinical evaluations at 3% confirmed the ingredient as safe, non-irritating, and non-sensitizing, demonstrating excellent tolerance across all skin types, including oily and acne-prone.
- 02 A related pentapeptide showed significant improvements over 4 weeks in fine wrinkles (+11% to +19%), skin compactness (+14%), and luminosity (+33% to +42%) in a topical application.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Highly stable in buffered aqueous solutions (e.g., PBS at pH 7.2), but sensitive to extreme heat. Incorporate into formulations during the cool-down phase below 40°C for optimal integrity.
Synergies
- other peptides (for anti-inflammatory benefits)
Conflicts
- strong oxidizers
- strong acids
- proteolytic enzymes
Safety
Safety Profile
While a dedicated CIR monograph is unavailable for this newer synthetic peptide, related pentapeptides are documented as safe, non-irritating, and non-sensitizing at concentrations up to 3%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Acetyl S-Cow Pentapeptide-1 SP is a valuable anti-aging peptide that boosts collagen, improves skin structure, and enhances luminosity with excellent skin compatibility across all skin types.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources