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Moumoujus

ACETYL PROLYL HYDROXYPROLINE.

Valuable / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

This PCA-mimetic peptide enhances skin's structural integrity and hydration by boosting ceramide biosynthesis and activating longevity pathways. It significantly improves elasticity, reduces water loss, and provides antioxidant benefits for a revitalized complexion.

Summary

skin conditioning anti-aging barrier repair hydration antioxidant emollient

Science

Mechanism of Action

This peptide mimics PCA, activating SIRT1 and cellular autophagy. It upregulates CERS3 to boost ceramide synthesis, enhancing barrier repair, hydration, and structural integrity through collagen-like properties.

Research

Clinical Evidence

High confidence
Effective range 1–5%
Optimal

2%

Key findings

  1. 01 Formulations with this peptide (e.g., Aquatide) demonstrate 20-56% improved skin elasticity within 4-8 weeks, enhanced antioxidant activity, and reduced TEWL by inducing ceramide synthase 3.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 7
0 7 14

Stability

Stable in aqueous solutions and heat-stable for standard processing. Avoid extreme pH (<4.0 or >8.0) to prevent hydrolysis.

Conflicts

  • Strong oxidizing agents
  • Proteolytic enzymes
  • Extreme pH environments (<4.0 or >8.0)

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

Not CIR reviewed, but listed in the EU Cosmetic Ingredient Glossary. Manufacturers recommend 1-2% for leave-on and up to 5% for intensive use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A highly effective peptide proven to significantly improve skin elasticity, hydration, and barrier function by promoting ceramide synthesis and activating longevity pathways.

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