Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

ACETYL OCTAPEPTIDE-3 OLIGOPEPTIDE-133.

Valuable / SKIN CONDITIONING

A sophisticated neurotransmitter-inhibiting peptide complex that mimics the N-terminal end of SNAP-25 protein to deliver Botox-like wrinkle reduction without injections. This dual-peptide system destabilizes the SNARE complex responsible for muscle contractions, effectively smoothing expression lines through topical application.

Summary

anti-aging skin conditioning wrinkle reduction

Science

Mechanism of Action

Competes for binding sites in the SNARE complex by mimicking SNAP-25, disrupting acetylcholine release at neuromuscular junctions and reducing facial muscle contractions that cause expression wrinkles

Research

Clinical Evidence

Medium confidence
Effective range 3–10%
Optimal

10%

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
1%
Red flag below
0.5%

Effective concentrations require 3-10% for meaningful neuromuscular inhibition; concentrations below 1% unlikely to provide significant anti-wrinkle benefits

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 6.5
0 7 14

Stability

Highly stable in aqueous solutions when added during cooling phase below 40°C to prevent peptide degradation

Synergies

  • other peptides in multi-peptide serums

Conflicts

  • strong oxidizing agents
  • proteolytic enzymes
  • pH extremes below 3 or above 7

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
10%
Sensitization risk Low

Generally recognized as safe for topical cosmetic use as peptide derivative with no specific regulatory restrictions

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Well-researched peptide complex with proven efficacy for expression line reduction, though requires meaningful concentrations above 3% for optimal results.

Related

Similar Ingredients

Finding similar ingredients…