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Moumoujus

ACETYL OCTAPEPTIDE-3.

Valuable CAS - / HUMECTANT, SKIN CONDITIONING

A synthetic octapeptide that functions as a topical neuromuscular modulator, designed to reduce expression lines by interfering with nerve signal transmission to facial muscles. Known commercially as SNAP-8, this peptide offers a non-invasive alternative to injectable treatments for dynamic wrinkles.

Summary

Cell-communicating ingredient Moisturizer/humectant Skin conditioning

Science

Mechanism of Action

Mimics the N-terminal end of the SNAP-25 protein to compete for binding sites in the SNARE complex, disrupting the release of neurotransmitters like acetylcholine from nerve endings and subsequently reducing muscle contractions that cause expression lines

Research

Clinical Evidence

Medium confidence
Effective range 3–10%
Optimal

10%

Key findings

  1. 01 28-day study with 10% solution (0.005% active peptide) showed 34.98% reduction in wrinkle depth versus 27.05% with Argireline
  2. 02 14-week multi-peptide clinical trial demonstrated significant improvement in eye lines (P=0.003) and eye wrinkles (P=0.007) by week 10

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
1%
Red flag below
0.5%

Given that effective concentrations require 3-10% of commercial solution containing 0.005% active peptide, products with minimal peptide content would be ineffective for neuromuscular modulation

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 6.5
0 7 14

Stability

Susceptible to hydrolysis at extreme pH values and prone to oxidation/deamidation due to methionine and aspartic acid residues; requires proper stabilization in slightly acidic environments

Synergies

  • Other peptides
  • Hyaluronic acid
  • Antioxidants

Conflicts

  • Strong oxidizers
  • Proteolytic enzymes
  • Extreme pH formulations

Safety

Safety Profile

CIR Status
Not reviewed by CIR
Max tested
10%
Sensitization risk Low

Safety profile inferred from related Acetyl Hexapeptide-8 which has been CIR-reviewed and deemed safe up to 0.005% pure peptide concentration

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A well-researched peptide with demonstrated efficacy for expression lines, though requiring proper formulation and adequate concentrations to deliver meaningful results.

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