Science
Mechanism of Action
Functions as a targeted signal peptide that upregulates synthesis of Collagen XVII and Syndecan-1 at the dermal-epidermal junction, enhancing the structural integrity between skin layers and improving overall skin density and resilience.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 21% reduction in wrinkle appearance and 15% improvement in skin firmness within 3 weeks of twice-daily application
Transparency
Dusting Analysis
Effective concentrations start at 0.1% with optimal results at 2%, making meaningful dusting unlikely in legitimate formulations
The Formula
Formulation
Stability
Thermally sensitive - must be incorporated below 40°C during cooling phase to preserve peptide integrity
Synergies
- Acetyl Tetrapeptide-9
- other signal peptides
- hyaluronic acid
Conflicts
- Strong oxidizing agents
- proteolytic enzymes
- extreme pH conditions
Safety
Safety Profile
Listed in EU CosIng and Global INCI inventories as safe skin-conditioning agent with no reported toxicological concerns at cosmetic use levels
Your Skin
Skin Compatibility
Our Assessment
Verdict
A well-researched peptide with demonstrated efficacy for improving skin firmness and reducing wrinkles through targeted dermal-epidermal junction enhancement.
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References
Sources