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Moumoujus

ACETYL OCTAPEPTIDE-2.

Valuable CAS - / SKIN CONDITIONING

A synthetic cell-communicating peptide that functions as a dual-action ingredient, targeting both expression lines through muscle contraction modulation and hair follicle stem cell activation. This acetylated octapeptide demonstrates enhanced enzymatic stability compared to its non-acetylated counterparts. Its versatility makes it valuable in both anti-aging skincare and hair growth applications.

Summary

cell-communicating ingredient skin conditioning hair conditioning anti-aging peptide

Science

Mechanism of Action

Works by mimicking natural signaling proteins to modulate cellular communication pathways. In anti-aging applications, it influences muscle contraction mechanisms to soften expression lines, while in hair and lash applications, it activates follicle stem cells to extend the anagen (growth) phase and boost keratin production.

Research

Clinical Evidence

Medium confidence
Effective range ≥0.005%
Optimal

0.005%

Key findings

  1. 01 Related octapeptide research demonstrates wrinkle depth reduction up to 34.98% with twice-daily application
  2. 02 In-vitro studies confirm increased cell growth, migration, and hair follicle stem cell activation

Transparency

Dusting Analysis

Not commonly dusted

Given effective concentrations around 0.005%, dusting is less likely to be commercially viable due to the relatively higher cost-per-gram of synthetic peptides

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

Maintains stability across pH 3.0-8.0 range, with optimal performance at physiological pH. Acetyl modification provides superior resistance to enzymatic breakdown compared to unmodified octapeptides.

Conflicts

  • Strong oxidizing agents
  • Formulations below pH 3.0 (peptide hydrolysis risk)
  • Highly alkaline environments above pH 8.0

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Considered safe based on similar octapeptide safety profiles and widespread use in sensitive-area products like eyelash serums

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A well-tolerated dual-purpose peptide with promising applications in both expression line reduction and hair growth, though clinical evidence remains primarily manufacturer-driven.

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