Science
Mechanism of Action
Binds to epidermal growth factor receptors (EGFR) on cell surfaces, triggering intracellular signaling cascades that promote epithelial cell proliferation and activate fibroblasts to increase collagen and elastin production, while also inhibiting neurotransmitter release involved in muscle contraction
Research
Clinical Evidence
Medium confidence0.005%
Key findings
- 01 Delivered 34.98% reduction in wrinkle depth versus 27.05% for Argireline after 28 days of twice-daily application
- 02 Achieved 43% inhibition of glutamate release in vitro, targeting neurotransmitter pathways involved in muscle contraction
Transparency
Dusting Analysis
With proven efficacy at 0.005%, concentrations below 0.001% would likely represent dusting rather than therapeutic dosing for this high-potency peptide
The Formula
Formulation
Stability
Requires cold storage at -20°C for raw material; stable at room temperature in finished formulations when protected from light and air; must be incorporated below 40°C to prevent thermal degradation
Synergies
- hyaluronic acid
- niacinamide
- antioxidants
Conflicts
- strong oxidizing agents
- proteolytic enzymes
- extreme pH environments
Safety
Safety Profile
While not individually assessed by CIR, structurally similar peptides like Acetyl Hexapeptide-8 Amide are deemed safe up to 0.005%; considered non-toxic and non-irritating at typical cosmetic concentrations
Your Skin
Skin Compatibility
Our Assessment
Verdict
A scientifically-backed peptide with demonstrated superior anti-aging performance at minimal concentrations, suitable for all skin types seeking advanced regenerative benefits.
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References
Sources